Evaluation of TCR-pMHC Affinity and its Implications for T Cell Therapies with Immudex & Quality Assistance

Webinar Recording & Slide Deck

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By filling out this form, you can access the webinar recording and the slide deck.

This webinar covers:

• Challenges associated with production of high quality TCR monomers suitable for TCR affinity measurement
• The importance of TCR affinity measurement in the context of development of T cell therapies
• Introduction to two techniques used for affinity measurement: Surface Plasmon Resonance and Biolayer Interferometry, and the advantages/disadvantages of each technique
• Results of a case study investigating the interaction between a modified affinity-enhanced TCR targeting the NY-ESO I antigen and its cognate pMHC (HLA-A*0201 / SLLMWITQC) in terms of affinity and kinetics
• Recommendations on best practices for TCR-pMHC affinity measurement

Speakers: 

• Lyn Zhu - R&D Scientist, Immudex
• Fabian Vandermeers - R&D Technical Leader, Quality Assistance